Key result
Renal supportive measures based on urinary (TIMP-2)*(IGFBP7) >0.3 significantly reduced the incidence of acute kidney injury compared to standard care (20.5% vs 29.9%, p < 0.05).
Why the study?
The study was conducted to assess urinary [TIMP-2]*[IGFBP7] for the prevention of acute kidney injury in patients undergoing elective cardiac surgery.
Does risk stratification using urinary (TIMP-2)*(IGFBP7) reduce the incidence of acute kidney injury in patients undergoing elective cardiac surgery?
Cohort (n=382)
Does risk stratification using urinary (TIMP-2)*(IGFBP7) reduce the incidence of acute kidney injury in patients undergoing elective cardiac surgery?
Absolute Event Rate: 20.5% vs 29.9%
p-value: p=< 0.05
Implementing renal supportive care based on urinary (TIMP-2)*(IGFBP7) risk stratification may significantly reduce the incidence of acute kidney injury following elective cardiac surgery.
Biomarker-guided renal support was associated with lower AKI incidence post-cardiac surgery; leaves open whether randomized trials will confirm benefit.
Aim: The purpose of this study was to assess urinary (TIMP-2)*(IGFBP7) for prevention of acute kidney injury (AKI) in patients undergoing elective cardiac surgery. Materials & methods: Two retrospective cohorts were analyzed before and after the implementation of urinary (TIMP-2)*(IGFBP7). The control cohort had a standard supportive care. For the (TIMP-2)*(IGFBP7) cohort, patients with the (TIMP-2)*(IGFBP7) >0.3 received renal supportive measures. Results: A total of 382 patients were included, 197 in the control cohort and 185 in intervention cohort. The incidence of AKI was significantly reduced in the (TIMP-2)*(IGFBP7) cohort (20.5 vs 29.9%, p < 0.05). In multivariate analysis, patients of the (TIMP-2)*(IGFBP7) cohort had a lower risk of developing AKI (p = 0.029). Conclusion: In conclusion, renal supporting care based on AKI risk stratification using urinary (TIMP-2)*(IGFBP7) may reduce AKI incidence.
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Couturier et al. (2021) conducted a cohort in Acute kidney injury (AKI) in patients undergoing elective cardiac surgery (n=382). Renal supportive measures based on urinary (TIMP-2)*(IGFBP7) >0.3 vs. Standard supportive care was evaluated on Incidence of acute kidney injury (AKI) (p=< 0.05). Renal supportive measures based on urinary (TIMP-2)*(IGFBP7) >0.3 significantly reduced the incidence of acute kidney injury compared to standard care (20.5% vs 29.9%, p < 0.05).
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