Key result
Hypomagnesemia enhances reperfusion injury via neurogenic inflammation, while Vitamin E supplements can prevent this enhanced injury by restoring endogenous antioxidant defenses.
Why the study?
Does Vitamin E supplementation prevent reperfusion injury in the setting of hypomagnesemia?
Does Vitamin E supplementation prevent reperfusion injury in the setting of hypomagnesemia?
Vitamin E supplementation may prevent enhanced myocardial reperfusion injury associated with hypomagnesemia by restoring endogenous antioxidant defenses.
Vitamin E should not yet change reperfusion practice in hypomagnesemia; hypothesis-generating and requires clinical trials.
In summary, hypomagnesemia enhances reperfusion injury. We postulate that neurogenic inflammation, which occurs very early during hypomagnesemia, predisposes the myocardium to reperfusion injury by depleting endogenous antioxidants and recruiting inflammatory cells, which can participate in enhanced free radical production during postischemic reperfusion. Vitamin E supplements can prevent the occurrence of this enhanced injury possibly through the restoration of endogenous antioxidant defenses.
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Weglicki et al. (1994) conducted a review in Hypomagnesemia and reperfusion injury. Vitamin E supplements was evaluated on Reperfusion injury. Hypomagnesemia enhances reperfusion injury via neurogenic inflammation, while Vitamin E supplements can prevent this enhanced injury by restoring endogenous antioxidant defenses.
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