A 6-week diet and exercise intervention in obese children improved flow-mediated dilation (P<0.05), which inversely correlated with changes in BMI, waist circumference, and inflammatory markers.
Does a 6-week diet and exercise intervention improve vascular function and inflammatory markers in obese children?
A short-term diet and exercise intervention in obese children improves endothelial function (FMD) and reduces adiposity, with improvements in vascular function correlating with reductions in oxidative stress and inflammation.
p-value: p=<0.05
BACKGROUND: The association of changes in oxidative and proinflammatory states with vascular function after diet and exercise intervention among obese children has not been previously explored. METHODS: In this 6-week diet and exercise intervention study in 35 obese children, age 12 to 18 years, we evaluated the relationship between changes in anthropometric indices, measures of insulin resistance, C-reactive protein (CRP), oxidized LDL (ox-LDL), and oxidative stress markers with changes in carotid intima-media thickness (C-IMT) and flow mediated dilation (FMD) of the brachial artery. RESULTS: At the end of the study, body mass index (BMI), waist circumference, and percentage body fat were decreased (P or = 95th percentile). Although FMD improved (P <0.05), the improvement in C-IMT did not reach statistical significance. The changes in BMI, waist circumference, fat mass, ox-LDL, malondialdehyde (MDA), CRP, insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) had an inverse correlation with the changes in mean FMD after adjustment for age and sex, with the highest correlations documented for ox-LDL, CRP, and WC. The age- and sex-adjusted changes in ox-LDL, waist circumference, CRP, MDA, and body fat mass had the highest correlations with changes in C-IMT. CONCLUSIONS: Our findings suggest that a common inflammatory stress condition associated with childhood obesity, notably with abdominal fat deposition, may play a role in the development of the earliest stages of proatherosclerotic inflammatory processes and subsequent vascular dysfunction. These changes might be partially reversible by short-term diet and exercise intervention, even if patients do not reach ideal body weight.
Kelishadi et al. (Mon,) conducted a other in obese children (n=35). diet and exercise intervention was evaluated on changes in carotid intima-media thickness (C-IMT) and flow mediated dilation (FMD) of the brachial artery (p=<0.05). A 6-week diet and exercise intervention in obese children improved flow-mediated dilation (P<0.05), which inversely correlated with changes in BMI, waist circumference, and inflammatory markers.