Key result
A 6-week diet and exercise intervention in obese children improved flow-mediated dilation (P<0.05), which inversely correlated with changes in BMI, waist circumference, and inflammatory markers.
Why the study?
Does a 6-week diet and exercise intervention improve vascular function and inflammatory markers in obese children?
Population
35 obese children, age 12 to 18 years
Design
Cohort
Follow-up
6 weeks
Authors
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May link oxidative changes to vascular function in obese youth; leaves open whether targeting these pathways improves outcomes.
Does a 6-week diet and exercise intervention improve vascular function and inflammatory markers in obese children?
p-value: p=<0.05
A short-term diet and exercise intervention in obese children improves endothelial function (FMD) and reduces adiposity, with improvements in vascular function correlating with reductions in oxidative stress and inflammation.
Kelishadi et al. (2007) studied obese children (n=35). diet and exercise intervention was evaluated on changes in carotid intima-media thickness (C-IMT) and flow mediated dilation (FMD) of the brachial artery (p=<0.05). A 6-week diet and exercise intervention in obese children improved flow-mediated dilation (P<0.05), which inversely correlated with changes in BMI, waist circumference, and inflammatory markers.
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