Key result
Dextran 70 had significant antithrombotic effects in small, severely traumatized veins, and this effect was enhanced by adding low-molecular-weight heparin without bleeding problems.
Why the study?
Does dextran 70 and/or low-molecular-weight heparin improve patency in small, severely traumatized veins?
Does dextran 70 and/or low-molecular-weight heparin improve patency in small, severely traumatized veins?
Dextran 70 combined with low-molecular-weight heparin improves patency in traumatized small veins without increasing bleeding risk in an experimental model.
Caution against clinical adoption in microsurgery; hypothesis-generating for combined regimens in traumatized vein models.
A clinical dose of dextran 70 had significant antithrombotic effects in small, severely traumatized veins, and the effect was enhanced by the addition of low-molecular-weight heparin. These effects were achieved without bleeding problems in this model.
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Zhang et al. (1994) studied this question. Dextran 70 had significant antithrombotic effects in small, severely traumatized veins, and this effect was enhanced by adding low-molecular-weight heparin without bleeding problems.
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