Key result
Anterior circumferential elastic modulus identified PCI candidates with 76.6% sensitivity and 83.3% specificity, while inferoseptal had 68.8% sensitivity and 70.8% specificity.
Why the study?
LV dysfunction can be assessed by quantifying LV structure, motivating the extraction of physical parameters including systolic strain, wall stress, and elastic modulus to diagnose stent candidate patients from control patients.
Can echocardiographic imaging parameters (strain, wall stress, elastic modulus) accurately identify PCI candidates among patients with CAD?
Observational (n=88)
Can echocardiographic imaging parameters (strain, wall stress, elastic modulus) accurately identify PCI candidates among patients with CAD?
Regional elastic modulus and strain parameters derived from echocardiography may serve as a noninvasive method to identify patients with CAD who are candidates for PCI.
Regional elastic modulus may aid noninvasive PCI candidate identification in CAD; hypothesis-generating and requires prospective validation.
PURPOSE: Left ventricular (LV) dysfunction can be assessed by quantifying LV structure. In this study, physical parameters were extracted, including the systolic strain, wall stress, and elastic modulus of LV to diagnose stent candidate patients from the control group. METHODS: Based on angiography results, 88 patients with coronary artery disease (CAD) were divided into 64 patients candidates for PCI (percutaneous coronary intervention) and 24 patients in the control group. With the thick-walled ellipsoidal model, the passive wall stresses at end-systole and end-diastole were estimated. Regional circumferential strain and regional longitudinal strain were obtained by speckle tracking technique. RESULTS: The inferoseptal circumferential wall stress in end-systole was statistically significant for the PCI group compared to the control group (p = .026). Anterior and inferoseptal circumferential strain for the PCI group (-17.25 ± 4.22 and -18.21 ± 4.04%) compared to the control group (-21.71 ± 4.74 and 20.58 ± 3.04%) were statistically significant, respectively (p = .000 and p = .011). Anterior and inferoseptal circumferential elastic modulus were statistically significant (p = .000 and p = .005). The receiver operator characteristic (ROC) curve analysis revealed that anterior and inferoseptal circumferential elastic modulus had the highest area under the curve with 76.6% sensitivity, 83.3% specificity for anterior circumferential, 68.8% sensitivity, and 70.8% specificity for inferoseptal circumferential, for the diagnosis of stent candidate patients. CONCLUSIONS: Regional elastic modulus parameter is suggested as a noninvasive and quantitative method for measuring LV function. Strain and stress parameters using the STE method and geometrical model can be helpful for diagnostic stent candidate patients.
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Ahmadi et al. (2022) conducted an observational in Coronary artery disease (CAD) (n=88). Candidate for percutaneous coronary intervention (PCI) vs. Control group was evaluated on Anterior and inferoseptal circumferential elastic modulus and strain (p=.000). Anterior circumferential elastic modulus identified PCI candidates with 76.6% sensitivity and 83.3% specificity, while inferoseptal had 68.8% sensitivity and 70.8% specificity.
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