Key result
Halothane anesthesia at 1.25 and 1.75 MAC significantly depressed left ventricular performance in healthy volunteers, decreasing mean arterial pressure and stroke work index (P<0.02).
Why the study?
Does general anesthesia with halothane alter left ventricular performance in healthy volunteers?
Population
n=6 healthy volunteers
Comparison
General anesthesia sequence: thiopental… vs Awake normal state
Design
Other
Follow-up
Acute (during anesthesia)
Authors
Loading...
Halothane may depress LV performance at clinical doses in healthy subjects; leaves open net effects in patients with cardiovascular disease.
Does general anesthesia with halothane alter left ventricular performance in healthy volunteers?
p-value: p=<0.02
Halothane anesthesia significantly depresses left ventricular performance in healthy subjects, and systolic time intervals should not be used for routine measurement during anesthesia unless loading conditions are known.
Filner et al. (1976) studied Healthy volunteers (n=6). Halothane general anesthesia vs. Awake state was evaluated on Left ventricular performance (mean arterial pressure and stroke work index) (p=<0.02). Halothane anesthesia at 1.25 and 1.75 MAC significantly depressed left ventricular performance in healthy volunteers, decreasing mean arterial pressure and stroke work index (P<0.02).