What is the clinical evidence from this study?

Study design: Observational. Population: Chronic His bundle block (n=16). Intervention: Chronic His bundle block. Primary outcome: Mortality.

What question did this study set out to answer?

To characterize the clinical, electrocardiographic, and electrophysiological features of chronic intra-His bundle block and assess long-term patient outcomes.

December 1, 1976HeartOpen Access

Chronic His bundle block. Clinical, electrocardiographic, electrophysiological, and follow-up studies on 16 patients.

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Key result

Among 16 patients with chronic His bundle block, 10 died during a follow-up period of 1 to 58 months, while 6 remained alive.

Population

16 patients with block within the His bundle, average age 76 years (range 42-98), 10 women and 6 men.

Design

Case_series

Follow-up

1 to 58 months

Authors

PGPriya GuptaWayne State College ELEdgar LichsteinAlbert Einstein College of Medicine KCKul D. ChaddaMount Sinai Hospital

Discussion

Member takes

Implication

Chronic His bundle block linked to high mortality; case series leaves open pacing survival benefit in larger studies.

Key Points

To characterize the clinical, electrocardiographic, and electrophysiological features of chronic intra-His bundle block and assess long-term patient outcomes.
Evaluated 16 consecutive patients (10 women and 6 men; mean age 76 years, range 42 to 98) identified over a 55-month period with block within the His bundle.
Conducted intracardiac His bundle electrophysiological recordings and administered intravenous atropine (1 to 2 mg) to assess atrioventricular conduction and escape rhythm responses.
Tracked clinical status and survival following management, including permanent pacemaker implantation in 12 patients, over a follow-up interval ranging from 1 to 58 months.
His bundle recordings demonstrated split His bundle potentials in 13 patients and narrow QRS with block distal to the His bundle potential in 3 patients.
Atrioventricular (AV) conduction presentations included complete heart block in 10 patients, second-degree AV block in 4 patients (2 Mobitz type II and 2 with 2:1 block), and first-degree AV block in 2 patients, with 10 exhibiting a narrow QRS.
Intravenous atropine produced variable effects on AV conduction and escape rate, and during follow-up, 10 patients died within 1 to 31 months while 6 patients (5 with pacemakers) survived up to 58 months.

Study Design

Type

Observational (n=16)

Structured PICO

Population

16 patients (average age 76 years, 62.5% female) with chronic His bundle block followed for 1 to 58 months.

Exposure

Permanent pacemaker implantation (n=12) and intravenous atropine (1 to 2 mg) testing.

Outcome

Mortality and clinical course during follow-up.hard clinical

Chronic His bundle block is associated with significant mortality, with survival observed primarily in patients who received a permanent pacemaker.

Cite This Study

Gupta et al. (1976) conducted an observational in Chronic His bundle block (n=16). Chronic His bundle block was evaluated on Mortality. Among 16 patients with chronic His bundle block, 10 died during a follow-up period of 1 to 58 months, while 6 remained alive.

synapsesocial.com/papers/6a6c810cf44fa9f079db4387 https://doi.org/10.1136/hrt.38.12.1343

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Chronic His bundle block. Clinical, electrocardiographic, electrophysiological, and follow-up studies on 16 patients.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Chronic His bundle block. Clinical, electrocardiographic, electrophysiological, and follow-up studies on 16 patients.

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

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