Key result
Administration of Moro orange, hawthorn fruit, tamarind pulp, and Gynostemma pentaphyllum leaf extracts reduced body weight gain by 27-49%, total cholesterol by 13-28%, and triglycerides by 40-52% compared to a high-fat diet alone in obese mice.
Why the study?
This study investigated the effects of Moro orange, hawthorn fruit, tamarind pulp, and Gynostemma pentaphyllum leaf extracts, given individually or combined, on blood lipid metabolism and anti-obesity activity in an animal model of high-fat diet-induced obesity.
Do extracts from Moro orange, hawthorn fruit, tamarind pulp, and Gynostemma pentaphyllum leaves improve blood lipid metabolism and reduce obesity in mice fed a high-fat diet?
Do extracts from Moro orange, hawthorn fruit, tamarind pulp, and Gynostemma pentaphyllum leaves improve blood lipid metabolism and reduce obesity in mice fed a high-fat diet?
Effect estimate: 27-49% reduction
p-value: p=<0.05
Plant extracts from Moro orange, hawthorn fruit, tamarind pulp, and Gynostemma pentaphyllum leaves demonstrated potential to improve lipid metabolism and reduce adiposity in a high-fat diet mouse model.
May support lipid modulation in HFD-obese animals; leaves open any human therapeutic role.
This study investigated the effects of extracts from Moro orange (Mor), hawthorn fruit (San), tamarind pulp (Tam), and Gynostemma pentaphyllum leaves (Dol), administered individually or in combination (MST and MSD), on blood lipid metabolism and anti-obesity activity in an animal model of obesity induced by a high-fat diet (HFD).Body weight, food intake, and blood lipid levels were monitored throughout the study.The HFD group, consuming only the high-fat diet, showed significant increases in body weight (approximately 2.4 times), total cholesterol (about 2.6 times), and triglycerides (about 1.7 times) compared to the normal control (NC) group.In contrast, in the extract-treated groups (Mor, San, Tam, Dol, MST and MSD), body weight gain was reduced by 27-49%, total cholesterol by 13-28%, and triglycerides by 40-52%.HDL-cholesterol levels increased by 1.5-1.6 times compared to the NC group, and while LDL-cholesterol rose by 2.8-3.9 times, it decreased overall compared to the HFD group.In the HFD group, abdominal fat and epididymal fat weights increased by about 1.4 times, respectively, and the size of adipocytes in epididymal fat tissue was significantly enlarged.However, the extract-treated groups showed a clear reduction in both abdominal and epididymal fat weights, as well as a significant decrease in adipocyte size.Additionally, the deposition of macrovesicular adipocytes in liver tissue observed prominently in the HFD group was notably suppressed in all extract-treated groups.These findings suggest that administering single or combined extracts has the potential to improve lipid metabolism and promote anti-obesity effects in mice fed a high-fat diet.
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Young Geol Yoon (2024) studied High-fat diet-induced obesity (n=40). Moro orange, hawthorn fruit, tamarind pulp, and Gynostemma pentaphyllum leaf extracts vs. High-fat diet only was evaluated on Body weight gain (27-49% reduction, p=<0.05). Administration of Moro orange, hawthorn fruit, tamarind pulp, and Gynostemma pentaphyllum leaf extracts reduced body weight gain by 27-49%, total cholesterol by 13-28%, and triglycerides by 40-52% compared to a high-fat diet alone in obese mice.
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