OBJECTIVE: To review the historical development of the psychopharmacological treatment of schizophrenia. METHOD: A chronological literature review of the clinical practices and theoretical models that have controlled drug treatment of schizophrenia at different times. RESULTS: Effective treatment of schizophrenia was achieved only after the introduction of antipsychotic drugs, in the 1950s, and is still progressing. CONCLUSION: Close collaboration between basic neuroscience and careful and informed clinical practice are likely to lead to continued progress.
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Lehmann et al. (1997) studied this question.
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