Key result
Isotonic Cs+ conditions enabled the isolation of the rapidly activating delayed rectifier potassium current (I(Kr)) in cardiac myocytes due to the unique high Cs+ permeability of I(Kr) channels.
Population
Isolated rabbit ventricular myocytes and human ether-a-go-go-related gene (hERG) channels
Design
Preclinical
Authors
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Cs+ enables I(Kr) isolation in myocytes; leaves open validation for intact-heart or clinical electrophysiology studies.
The unique high Cs+ permeability in I_Kr channels provides an effective way to isolate and record I_Kr current, which is useful for exploring its role in arrhythmias associated with heart failure and long QT syndrome.
Shetuan Zhang (2005) studied this question. Isotonic Cs+ conditions was evaluated on I(Kr) current isolation. Isotonic Cs+ conditions enabled the isolation of the rapidly activating delayed rectifier potassium current (I(Kr)) in cardiac myocytes due to the unique high Cs+ permeability of I(Kr) channels.
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