Key result
Chronic AV block-induced hypertrophy in dogs reduced KCNE1 and KCNQ1 RNA by 70% and 80%, and protein levels by 60% and 50%, respectively, explaining the reduction in I(Ks).
Population
Canine model of chronic AV block (CAVB)-induced hypertrophy
Comparison
Chronic AV block (CAVB)-induced hypertrophy vs Normal dogs
Design
Preclinical
Authors
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Animal model data on I(Ks) reduction should not guide human care; leaves open translational relevance for acquired long QT.
In a canine model of hypertrophy, the reduction in IKs is driven by transcriptional down-regulation of KCNE1 and KCNQ1, providing a molecular basis for acquired long QT and torsade de pointes.
Christian Ramakers (2003) studied Chronic AV block-induced hypertrophy. Chronic AV block (CAVB)-induced hypertrophy vs. Normal dogs was evaluated on KCNE1 and KCNQ1 RNA and protein levels. Chronic AV block-induced hypertrophy in dogs reduced KCNE1 and KCNQ1 RNA by 70% and 80%, and protein levels by 60% and 50%, respectively, explaining the reduction in I(Ks).
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