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October 30, 2020Journal of Diabetes ResearchOpen Access

Combination of Composite Autonomic Symptom Score 31 and Heart Rate Variability for Diagnosis of Cardiovascular Autonomic Neuropathy in People with Type 2 Diabetes

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Why the study?

Cardiovascular autonomic neuropathy is a common and severe complication of diabetes, making timely diagnosis clinically important.

Does the combination of COMPASS 31 and HRV improve the diagnostic performance for cardiovascular autonomic neuropathy in patients with type 2 diabetes?

Population

103 hospitalized subjects with type 2 diabetes

Comparison

COMPASS 31 combined with HRV vs CARTs reference standard

Design

Diagnostic study

Key result

Combining the COMPASS 31 score with HRV indices (SDNN and LF) identified cardiovascular autonomic neuropathy in type 2 diabetes with an AUC of 0.958, 90.7% sensitivity, and 86.7% specificity.

Authors

ZZZhiyong ZhangYMYujin MaLFLiujun Fu

Discussion

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Overview

May support combined COMPASS 31-HRV use for CAN screening in diabetes; leaves open need for prospective validation before practice change.

Study Design

Type

Cross-Sectional (n=103)

Structured PICO

Does the combination of COMPASS 31 and HRV improve the diagnostic performance for cardiovascular autonomic neuropathy in patients with type 2 diabetes?

P
Population
103 hospitalized subjects with type 2 diabetes evaluated for cardiovascular autonomic neuropathy.
E
Exposure
Combination of Composite Autonomic Symptom Score 31 (COMPASS 31) and heart rate variability (HRV) indices (SDNN and LF)
C
Comparator
COMPASS 31 alone or HRV indices alone, compared against cardiovascular autonomic reflex tests (CARTs) as the reference standard
O
Outcome
Diagnostic performance (AUC, sensitivity, specificity) for cardiovascular autonomic neuropathy (CAN)surrogate

Main Result

Effect estimate: AUC 0.958

Combining the COMPASS 31 symptom score with heart rate variability indices (SDNN and LF) provides high diagnostic accuracy for cardiovascular autonomic neuropathy in patients with type 2 diabetes.

Cite This Study

Zhang et al. (2020) conducted a cross-sectional in Type 2 diabetes with suspected cardiovascular autonomic neuropathy (n=103). Combination of COMPASS 31 score and HRV indices (SDNN and LF) vs. Individual tests (COMPASS 31 or HRV alone) was evaluated on Diagnosis of cardiovascular autonomic neuropathy (CAN) (AUC 0.958). Combining the COMPASS 31 score with HRV indices (SDNN and LF) identified cardiovascular autonomic neuropathy in type 2 diabetes with an AUC of 0.958, 90.7% sensitivity, and 86.7% specificity.

synapsesocial.com/papers/6a6c8b9a2163a0a01bc2884bhttps://doi.org/10.1155/2020/5316769
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autonomic Symptoms and Diabetic Neuropathy2004 · 321 citations
  2. 2Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation2014 · 53 citations
  3. 3Cardiovascular Autonomic Dysfunction Predicts Severe Hypoglycemia in Patients With Type 2 Diabetes: A 10-Year Follow-up Study2013 · 47 citations
  4. 4Cardiac Autonomic Neuropathy in Diabetes2010 · 476 citations
  5. 5Cardiac Outcomes After Screening for Asymptomatic Coronary Artery Disease in Patients With Type 2 Diabetes2009 · 817 citations