Key result
Hypertension linked to ~27% lower gingival crevicular PGE2 levels in periodontitis.
Why the study?
Prostaglandin E2 is implicated in chronic inflammatory diseases including periodontitis and regulates blood pressure, prompting comparison of prostaglandin levels in gingival crevicular fluid between hypertensive and non-hypertensive periodontitis patients.
Are Prostaglandin E2 levels in gingival crevicular fluid higher in periodontitis patients with hypertension compared to those without hypertension?
Observational (n=62)
No
Are Prostaglandin E2 levels in gingival crevicular fluid higher in periodontitis patients with hypertension compared to those without hypertension?
Hypertension in periodontitis patients is associated with higher levels of the inflammatory mediator PGE2 and worse periodontal clinical parameters.
Hypertension-associated lower gingival PGE2 in periodontitis is hypothesis-generating; leaves open inflammatory interactions and requires prospective validation before clinical consideration.
Objective: Periodontitis is an infection that involved tooth-supporting tissues by dental plaque biofilm on the tooth surface and host immune responseas causal to as inflammation resolution. Prostaglandin E2 (PGE2) as an inflammatory mediator has been implicated in the pathogenesis of variouschronic inflammatory diseases, including periodontitis, and as a regulator of blood pressure. This study aims to compare the levels of prostaglandinin the gingival crevicular fluid (GCF) of periodontitis patients with hypertension and non-hypertension.Methods: A total sample of 62 patients was examined and consists of 44 patients (aged 50–90 years) who were hypertension group and 18 patients(aged 30–49 years) who were non-hypertension groups as a control. Hypertension state was measured by blood pressure based on anamnesisand using sphygmomanometer mercury. The clinical sample was collected from 62 gingival crevicular fluids [GCF] of periodontal disease subject.Measurement of the clinical parameter of probing pocket depth [PD], and bleeding on probing [BOP ≥1] was included as a diagnostic requisition.The PD and clinical attachment loss [CAL] was defined as present if the PD was ≥5 mm and CAL was ≥1 mm. Prostaglandin E2 level was estimated ingingival crevicular fluid samples by using the enzyme-linked immunosorbent assay.Results: The level of PGE2 was statistically significant difference in hypertension patient compare with non-hypertension (p<0.05). There was asignificant difference in PD, recession, and CAL (p<0.05).Conclusion: Higher blood pressure might be related to the potential risk of inflammation and progression periodontal disease.
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Priharnanto et al. (2020) conducted an observational in Periodontitis (n=62). Hypertension vs. Non-hypertension was evaluated on Prostaglandin E2 (PGE2) level in gingival crevicular fluid (pg/mL) (p=0.002). Hypertension was associated with significantly lower levels of prostaglandin E2 in the gingival crevicular fluid of patients with periodontitis compared to non-hypertensive patients.
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