Key result
The complete high-resolution structure of the 200 kDa α-actinin-2 dimer from striated muscle was determined, providing insight into its phosphoinositide-based regulation and interaction with titin.
Population
Human muscle α-actinin-2 dimer from striated muscle
Design
Preclinical
Authors
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High-resolution α-actinin-2 structure advances Z-disk mechanics insight; leaves open links to cardiomyopathy mechanisms or therapies.
The high-resolution structure of human muscle α-actinin-2 provides insights into its regulation and interaction with sarcomeric proteins, laying a foundation for studying pathogenic mutations.
Ribeiro et al. (2014) studied this question. The complete high-resolution structure of the 200 kDa α-actinin-2 dimer from striated muscle was determined, providing insight into its phosphoinositide-based regulation and interaction with titin.
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