Transfusion-related Acute Lung Injury During Intravenous Immunoglobulin Treatment

A 71-year-old woman with Sjogren’s syndrome and giant cell arteritis was treated with intravenous immunoglobulin (IVIG) (6 g protein/250 ml, stabilized with sucrose 10 g/flacon, NaCl 0.02 g/g protein) for peripheral sensory motor neuropathy — an unlabeled use of the drug1,2. The dose of IVIG was 400 mg/kg/day for 5 days. During administration of the third flacon of IVIG (12 grams had been already infused over 4 hours …