What question did this study set out to answer?

To comparatively evaluate the clinical relevance and diagnostic accuracy of a component-based allergen-microarray versus standard ImmunoCAP assays across five common aeroallergens in patients with allergic rhinoconjunctivitis.

March 30, 2006Allergy

The performance of a component‐based allergen‐microarray in clinical practice

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Authors

SWStefan WöhrlAllergiezentrum Wien West KVKornelia ViglRudolfinerhaus Hospital SZSonja ZehetmayerMedical University of Vienna

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Implication

Prospective double-centre study demonstrates diagnostic equivalence between allergen microarrays and standard assays for common aeroallergens, suggesting microarrays effectively identify select...

Key Points

To comparatively evaluate the clinical relevance and diagnostic accuracy of a component-based allergen-microarray versus standard ImmunoCAP assays across five common aeroallergens in patients with allergic rhinoconjunctivitis.
Enrolled 120 subjects in a prospective, double-centre study.
Identified allergic subjects by clinical history and concomitant positive skin-prick tests (SPT) to natural extracts of house dust mite, cat dander, birch, grass, and mugwort pollen.
Measured specific serum IgE using both the component-based allergen-microarray and ImmunoCAP for individual allergen evaluation.
Microarray performance was equivalent to ImmunoCAP on ROC curve analysis for cat dander (AUC 0.950 vs 0.894, P = 0.211), birch pollen (AUC 0.908 vs 0.878, P = 0.483), and grass pollen (AUC 0.923 vs 0.915, P = 0.770).
Microarray sensitivity was slightly lower for house dust mite (AUC 0.808 vs 0.911, P = 0.053) and significantly reduced for mugwort pollen (AUC 0.723 vs 0.879, P = 0.032).

Cite This Study

Wöhrl et al. (2006) studied this question.

synapsesocial.com/papers/6a6c925dfebe604dd7078c33 https://doi.org/10.1111/j.1398-9995.2006.01078.x

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Implication

Prospective double-centre study demonstrates diagnostic equivalence between allergen microarrays and standard assays for common aeroallergens, suggesting microarrays effectively identify select...

The performance of a component‐based allergen‐microarray in clinical practice

Discussion

Member takes

Implication

Key Points

Cite This Study

The performance of a component‐based allergen‐microarray in clinical practice

Discussion

Member takes

Implication

Key Points

Cite This Study

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