Key result
Basal potassium conductance in human and guinea pig atrial cells was mainly due to iK1 channels, with acetylcholine-induced currents playing only a modulatory role in human cells.
Basal potassium conductance in human atrial cells is primarily driven by iK1 channels, with acetylcholine-sensitive channels playing a smaller modulatory role compared to guinea pig models, highlighting species-specific differences in autonomic modulation.
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Provides foundational human atrial K+ channel data; extends animal models but leaves clinical translation open.
Heidbüchel et al. (1990) studied this question. Acetylcholine and adenosine vs. Basal conditions was evaluated on Single-channel characteristics and contribution to total basal potassium conductance. Basal potassium conductance in human and guinea pig atrial cells was mainly due to iK1 channels, with acetylcholine-induced currents playing only a modulatory role in human cells.
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