What does this research mean for the field?

Mammalian atrial muscarinic potassium channels are directly activated by a specific G protein (Gk), demonstrating that ion channels, and not just enzymes, can be directly controlled by receptor-coupling G proteins. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

January 9, 1987Science

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G k

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Population

Isolated, inside-out patches of membranes from mammalian atrial cells

Design

Preclinical

Authors

AYAtsuko YataniElectrophysiology JCJuan CodinaElectrophysiology ABArthur BrownRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Questions enzyme-dependent models of muscarinic K+ channel control; leaves open direct G protein gating in human atria.

Structured PICO

Population

Isolated, inside-out patches of membranes from mammalian atrial cells

Intervention

Purified pertussis toxin-sensitive G protein (Gk) of subunit composition alpha beta gamma

Outcome

Activation of potassium channels

This study provides foundational evidence that mammalian atrial muscarinic potassium channels are directly activated by a G protein, demonstrating that ion channels can be controlled by receptor-coupling G proteins without intermediary enzymes.

Cite This Study

Yatani et al. (1987) studied this question.

synapsesocial.com/papers/6a11dd853e1890633cb4dcfb https://doi.org/10.1126/science.2432660

View Full Paper

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January 9, 1987Science

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G k

View Full Paper

Ask AI

Bookmark

Population

Isolated, inside-out patches of membranes from mammalian atrial cells

Design

Preclinical

Authors

AYAtsuko YataniElectrophysiology JCJuan CodinaElectrophysiology ABArthur BrownRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Questions enzyme-dependent models of muscarinic K+ channel control; leaves open direct G protein gating in human atria.

Structured PICO

Population

Isolated, inside-out patches of membranes from mammalian atrial cells

Intervention

Purified pertussis toxin-sensitive G protein (Gk) of subunit composition alpha beta gamma

Outcome

Activation of potassium channels

Cite This Study

Yatani et al. (1987) studied this question.

synapsesocial.com/papers/6a11dd853e1890633cb4dcfb https://doi.org/10.1126/science.2432660

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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