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November 1, 1993Proceedings of the National Academy of SciencesOpen Access

Atrial G protein-activated K+ channel: expression cloning and molecular properties.

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Population

Rat atrium cDNA library expressed in Xenopus oocytes

Design

Preclinical

Authors

NDNathan DascalElectrophysiologyWSWolfgang SchreibmayerCalifornia Institute of TechnologyNLNancy LimCalifornia Institute of Technology

Discussion

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Implication

Molecular identification of atrial G-protein K+ channel enables mechanistic studies; leaves open arrhythmia treatment implications.

Structured PICO

P
Population
Rat atrium cDNA library expressed in Xenopus oocytes
I
Intervention
Cloning and functional expression of the atrial G protein-activated K+ channel (KGA)
O
Outcome
Channel activation and conductance properties

The cloning of the atrial G protein-activated K+ channel (KGA) provides a molecular basis for understanding the membrane-delimited pathway regulating the heartbeat.

Cite This Study

Dascal et al. (1993) studied this question.

synapsesocial.com/papers/6a715589f44fa9f079df21d4https://doi.org/10.1073/pnas.90.21.10235
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rectification of muscarinic K+ current by magnesium ion in guinea pig atrial cells1987 · 60 citations
  2. 2On the mechanism of G protein beta gamma subunit activation of the muscarinic K+ channel in guinea pig atrial cell membrane. Comparison with the ATP-sensitive K+ channel.1992 · 199 citations
  3. 3The nature and origin of spontaneous noise in G protein-gated ion channels.1991 · 43 citations