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Shows that lysyl oxidase remodeling of the extracellular matrix drives aortic stiffness in chronic kidney disease, highlighting a therapeutic target to improve cardiovascular outcomes.
Arterial stiffness in CKD is associated with adverse cardiovascular outcomes. However, the mechanisms underlying increased aortic stiffness in CKD are unclear. Herein, we demonstrated that 1) increased aortic stiffness in CKD is independent of hypertension and calcification and 2) LOX-mediated changes in extracellular matrix are at least in part responsible for increased aortic stiffness in CKD. Prevention of excess LOX may have therapeutic potential in alleviating increased aortic stiffness and improving cardiovascular disease in CKD.
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Sharma et al. (2023) studied this question.
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