What is the clinical evidence from this study?

Study design: Review. Population: Glucose and lipid metabolism disorders (GLMDs) and cardiovascular injuries.

October 17, 2025Reviews in Cardiovascular MedicineOpen Access

Advances in Molecular Mechanisms and Precision Interventions of Cardiovascular Injuries Related to Glucose and Lipid Metabolism Disorders

View Full Paper

Ask AI

Bookmark

Key result

Glucose and lipid metabolism disorders drive cardiovascular injury via metabolic inflammation, lipotoxicity, metabolic memory, and gut dysbiosis, providing novel targets for precision interventions.

Design

Review

Authors

LWLi WuHunan University of Traditional Chinese Medicine JXJiyao XuShanxi Cardiovascular Hospital CWChenxia WuZhejiang Chinese Medical University

Discussion

Member takes

Implication

Novel metabolic targets merit investigation in cardiometabolic disease; leaves open clinical translation pending prospective trials.

Structured PICO

Population

Patients with glucose and lipid metabolism disorders (GLMDs) at risk for or with cardiovascular injuries, specifically atherosclerotic cardiovascular disease (ASCVD), diabetic cardiomyopathy (DbCM), heart failure (HF), and cardiac autonomic neuropathy (CAN).

Intervention

Precision interventions targeting molecular mechanisms (e.g., SGLT2 inhibitors, ACBP/TGR5 targeting, microbiota regulation).

This review synthesizes the molecular mechanisms linking glucose and lipid metabolism disorders to cardiovascular disease, highlighting novel therapeutic targets such as the cGAS-STING pathway and metabolic memory.

Limitations

Heterogeneity of GLMD requires molecular subtyping
Need for tissue-targeted delivery systems to avoid off-target effects
Dynamic multi-omics-AI risk prediction models require prospective validation

Cite This Study

Wu et al. (2025) conducted a review in Glucose and lipid metabolism disorders (GLMDs) and cardiovascular injuries. Glucose and lipid metabolism disorders drive cardiovascular injury via metabolic inflammation, lipotoxicity, metabolic memory, and gut dysbiosis, providing novel targets for precision interventions.

synapsesocial.com/papers/6a6cac31f44fa9f079db5656 https://doi.org/10.31083/rcm42406

View Full Paper

Ask AI

Bookmark

Advances in Molecular Mechanisms and Precision Interventions of Cardiovascular Injuries Related to Glucose and Lipid Metabolism Disorders

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Advances in Molecular Mechanisms and Precision Interventions of Cardiovascular Injuries Related to Glucose and Lipid Metabolism Disorders

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider