Key result
During the COVID-19 pandemic, patients presenting with STEMI exhibited a higher coronary thrombotic burden compared to the pre-pandemic period, without a significant change in in-hospital mortality.
Why the study?
Coronavirus disease 2019 is thought to be prothrombotic, which could potentially affect atherothrombotic diseases.
Does STEMI presentation during the COVID-19 pandemic increase coronary thrombotic burden compared to the pre-pandemic period?
Observational (n=277)
No
Does STEMI presentation during the COVID-19 pandemic increase coronary thrombotic burden compared to the pre-pandemic period?
Answers are grounded in this paper and cite their sources.
STEMI patients during the COVID pandemic exhibited higher coronary thrombotic burden; leaves open whether infection directly drives atherothrombosis and requires prospective confirmation.
Background: Coronavirus disease 2019 ) is thought to be prothrombotic, and this can affect atherothrombotic diseases.Methods: This is a single-center retrospective observational study conducted on patients with ST-segment-elevation myocardial infarctions.We enrolled 277 subjects, respectively, between 1 March and 31 December 2019 (cohort A, N° 85), 1 March and 31 December 2020 (cohort B, N° 76) and 1 March and 31 December 2021 (cohort C, N° 116).The coronary thrombotic burden was assessed using the thrombus grade score.Results: Patients in cohorts B and C present a higher coronary thrombosis burden than patients in cohort A. However, this does not correlate with worse clinical outcomes; in fact, there is neither an increase in hospitalization days nor a reduction in left-ventricle ejection fractions, and the in-hospital death rate is similar among the three patient cohorts.There are no significant differences in the incidence of non-coronary thrombotic events.The subgroup of vaccinated patients in cohort C present no significant differences in coronary thrombotic burden.Conclusions: In patients with ST-segment-elevation myocardial infarctions during the COVID-19 pandemic, an increase in coronary thrombotic burden is observed while the in-hospital death rate does not change significantly.
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Biancofiore et al. (2022) conducted an observational in ST-segment-elevation myocardial infarction (STEMI) (n=277). COVID-19 pandemic period (2020-2021) vs. Pre-pandemic period (2019) was evaluated on Modified thrombus grade post first device (p=0.001). During the COVID-19 pandemic, patients presenting with STEMI exhibited a higher coronary thrombotic burden compared to the pre-pandemic period, without a significant change in in-hospital mortality.
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