Key result
Homozygous sickle cell anaemia linked to ~6-point lower LVEF vs controls, driven by symptomatic patients.
Case-Control (n=72)
Answers are grounded in this paper and cite their sources.
Left ventricular performance was determined by echocardiography in 44 black children with homozygous sickle cell anaemia and a control group of 28 normal black children of comparable age. Statistically significant differences were observed between the children with sickle cell anaemia and the normal group in left ventricular ejection fraction (sickle cell anaemia group: 0-59 + 0.01 [mean + standard error of the mean] vs. normal group: 0-65 + 0.01), cardiac index (5.3 + 0 3 vs 4-2 + 0 3 1/min per i2), mean circumferential fibre shortening velocity (116 + 0 04 vs 1-31 + 0.03s-1) and the per- centage of shortening of left ventricular minor axis dimension (32.5 + 1 vs 36-7 + 0.8). The children with sickle cell anaemia were divided into two groups according to the absence or presence of dyspnoea and/or fatigue on moderate effort; though both groups had the same degree of anaemia, significantly depressed left ventricular performance indices were observed only in the group of symptomatic patients. All asymptomatic children with sickle-cell anaemia had uncompromised left ventricular performance.
No takes yet. Share an insight, caveat, or question.
Rees et al. (1978) conducted a case-control in Homozygous sickle cell anaemia (n=72). Homozygous sickle cell anaemia vs. Normal black children was evaluated on Left ventricular ejection fraction. Children with homozygous sickle cell anaemia had significantly lower left ventricular ejection fraction (0.59 vs 0.65) compared to normal controls, driven by symptomatic patients.
Synapse has enriched 10 related papers. Consider them for comparative context: