Key result
Enalapril significantly reduced albuminuria in nephrotic rats fed a high-protein diet (136 vs 368 mg/day, P<0.05) and in rats with established proteinuria (423 to 169 mg/day, P<0.001).
Why the study?
Does enalapril reduce albuminuria in nephrotic rats fed varying levels of dietary protein?
Population
Rats with passive Heymann nephritis fed 40% (high protein), 8.5% (low protein), or 21% (normal protein) diets
Comparison
Enalapril beginning 2 days after injection of… vs No enalapril (control groups on respective diets)
Design
Preclinical
Follow-up
3 days (for established proteinuria group)
Authors
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ACEI may blunt high-protein effects on albuminuria in experimental nephrosis; leaves open human translation.
Does enalapril reduce albuminuria in nephrotic rats fed varying levels of dietary protein?
Absolute Event Rate: 136% vs 368%
p-value: p=<0.05
Enalapril reduces albuminuria in nephrotic rats on normal or high protein diets without modifying GFR, suggesting changes in glomerular hemodynamics or permselectivity.
Hutchinson et al. (1987) studied Passive Heymann nephritis (nephrotic rats). Enalapril vs. No enalapril was evaluated on Albuminuria (UalbV) in high-protein diet rats (p=<0.05). Enalapril significantly reduced albuminuria in nephrotic rats fed a high-protein diet (136 vs 368 mg/day, P<0.05) and in rats with established proteinuria (423 to 169 mg/day, P<0.001).
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