Key result
Aortic microsphere infusion via Silastic catheters provided uniform microsphere distribution and equivalent blood flow measurements to left ventricular infusion in exercising rats.
Population
Rats (anesthetized and conscious, exercising on a high-speed treadmill)
Comparison
Silastic catheters placed in the ascending aorta… vs Left ventricular (LV) infusion
Design
Preclinical
Authors
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New Silastic catheter placement enables reliable microsphere blood flow measurement during rat running; leaves open translation to human cardiovascular exercise studies.
Aortic microsphere infusion with renal artery withdrawal is a valid technique for measuring skeletal muscle blood flow in exercising rats.
Laughlin et al. (1982) studied Exercising rats (animal model). Aortic microsphere infusion via Silastic catheters vs. Left ventricular (LV) infusion was evaluated on Muscle blood flow and microsphere-blood mixing. Aortic microsphere infusion via Silastic catheters provided uniform microsphere distribution and equivalent blood flow measurements to left ventricular infusion in exercising rats.
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