Key result
Infarct-related regional CMR parameters were superior to global parameters in predicting left ventricular remodeling after AAMI (AUC 0.917 vs 0.832; P=0.002).
Why the study?
Heart failure frequently complicates left ventricular remodeling after acute anterior myocardial infarction, making it crucial to identify predictive parameters for remodeling following primary percutaneous coronary intervention.
Does early cardiovascular magnetic resonance (CMR) predict left ventricular remodeling at 6 months in patients with acute anterior myocardial infarction following PPCI?
Cohort (n=128)
Does early cardiovascular magnetic resonance (CMR) predict left ventricular remodeling at 6 months in patients with acute anterior myocardial infarction following PPCI?
Effect estimate: AUC 0.917 (95% CI 0.870-0.965)
p-value: p=<0.001
Early regional CMR parameters, specifically infarct size and peak circumferential strain in infarcted segments, are highly predictive of left ventricular remodeling at 6 months in patients with acute anterior myocardial infarction.
May support CMR parameters predicting LVR post-PPCI in AAMI; leaves open prospective validation before clinical adoption.
Background: Heart failure is a serious complication resulting from left ventricular remodeling (LVR), especially in patients experiencing acute anterior myocardial infarction (AAMI). It is crucial to explore the predictive parameters for LVR following primary percutaneous coronary intervention (PPCI) in patients with AAMI. Methods: A total of 128 AAMI patients who were reperfused successfully by PPCI were enrolled sequentially from June 2018 to December 2019. Cardiovascular magnetic resonance (CMR) was performed at the early stage (<7 days) and after the 6-month follow-up. The patients were divided into LVR and non-LVR groups according to the increase of left ventricular end diastolic volume (LVEDV) measured by the second cardiac magnetic resonance examination ≥20% from baseline. (3) Results: The left ventricular ejection fraction (LVEF), the global longitudinal strain (GLS), the peak circumferential strain in infarcted segments, and the infarct size (IS) remained significantly different in the multivariate logistic regression analysis (all p < 0.05). The area under the receiver operating characteristic curve of Model 1, wherein the GLS was added to the LVEF, was 0.832 (95% CI 0.758−0.907, p < 0.001). The C-statistics for Model 2, which included the infarct-related regional parameters (IS and the peak circumferential strain in infarcted segments)was 0.917 (95% CI 0.870−0.965, p < 0.001). Model 2 was statistically superior to Model 1 in predicting LVR (IDI: 0.190, p = 0.002). (4) Conclusions: Both the global and regional CMR parameters were valuable in predicting LVR in patients with AAMI following the PPCI. The local parameters of the infarct zones were superior to those of the global ones.
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Ma et al. (2022) conducted a cohort in Acute anterior myocardial infarction (n=128). Infarct-related regional CMR parameters vs. Global CMR parameters was evaluated on Left ventricular remodeling (LVEDV increase ≥20% from baseline) (AUC 0.917, 95% CI 0.870-0.965, p=<0.001). Infarct-related regional CMR parameters were superior to global parameters in predicting left ventricular remodeling after AAMI (AUC 0.917 vs 0.832; P=0.002).
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