What question did this study set out to answer?

To determine whether concurrent hyper-reactivity of mononuclear cells and neutrophils occurs in patients with chronic periodontitis and whether it correlates with the IL-1beta(+3953) gene polymorphism.

January 27, 2006Journal Of Clinical Periodontology

Hyper‐reactive mononuclear cells and neutrophils in chronic periodontitis

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Authors

AGAnders GustafssonKarolinska Institutet HIH. ItoNiigata University Medical and Dental Hospital BÅB. ÅsmanKarolinska University Hospital

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Implication

Case-control study reveals heightened leukocyte cytokine release and radical production in chronic periodontitis, suggesting intrinsic immune hyper-reactivity drives tissue damage.

Key Points

To determine whether concurrent hyper-reactivity of mononuclear cells and neutrophils occurs in patients with chronic periodontitis and whether it correlates with the IL-1beta(+3953) gene polymorphism.
Enrolled 14 non-smoking, well-treated periodontitis patients and pair-matched healthy controls.
Measured IL-1beta and TNF-alpha release via ELISA after stimulating peripheral mononuclear cells with lipopolysaccharide and opsonized Staphylococcus aureus.
Assessed neutrophil oxygen radical generation via chemiluminescence following Fcgamma-receptor stimulation and genotyped the IL-1beta(+3953) polymorphism using PCR.
Mononuclear cells from periodontitis patients released significantly higher levels of IL-1beta upon stimulation with lipopolysaccharide (p < 0.001) and bacteria (p < 0.05), alongside a trend toward elevated TNF-alpha.
Peripheral neutrophils from patients generated more oxygen radicals compared to controls (p < 0.06).
No differences were identified between patients and controls regarding the IL-1beta(+3953) gene polymorphism.

Cite This Study

Gustafsson et al. (2006) studied this question.

synapsesocial.com/papers/6a6cc1fe2163a0a01bc29b10 https://doi.org/10.1111/j.1600-051x.2005.00883.x

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Implication

Case-control study reveals heightened leukocyte cytokine release and radical production in chronic periodontitis, suggesting intrinsic immune hyper-reactivity drives tissue damage.

Hyper‐reactive mononuclear cells and neutrophils in chronic periodontitis

Discussion

Member takes

Implication

Key Points

Cite This Study

Hyper‐reactive mononuclear cells and neutrophils in chronic periodontitis

Discussion

Member takes

Implication

Key Points

Cite This Study

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