Key result
Co-administration of a CD40-expressing plasmid with DNA vaccines in mice induced anti-CD40 antibodies, augmenting humoral responses and promoting T cell activation.
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May warrant testing CD40 plasmids as DNA vaccine adjuvants; leaves open translation beyond murine models.
Xu et al. (2009) studied DNA vaccination efficacy. CD40-expressing plasmid (pcD-CD40) was evaluated on Immune response (anti-CD40 antibody induction and augmented production of anti-VP1 antibody). Co-administration of a CD40-expressing plasmid with DNA vaccines in mice induced anti-CD40 antibodies, augmenting humoral responses and promoting T cell activation.
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