Key result
Decreases in Ca2+-calmodulin-dependent MLC phosphorylation contribute to the decline in isometric force at lengths below optimal length, but quick release depression is not caused by deactivation.
Population
Tracheal smooth muscle
Comparison
Changing smooth muscle length before or during… vs Contraction at optimal length (Lo)
Design
Preclinical
Authors
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Shortening deactivation in vitro should not guide practice; leaves open Ca2+ or MLC mediation in intact myocardium.
Decreases in Ca2+-calmodulin-dependent MLC phosphorylation contribute to the decline in isometric force at shorter muscle lengths, but not to the depression of contractility following quick release during contraction.
Mehta et al. (1996) studied this question. Changing smooth muscle length vs. Optimal length (Lo) was evaluated on Isometric force, intracellular Ca2+, and myosin light chain (MLC) phosphorylation. Decreases in Ca2+-calmodulin-dependent MLC phosphorylation contribute to the decline in isometric force at lengths below optimal length, but quick release depression is not caused by deactivation.
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