Key result
Neglecting surrounding tissue in computational models overestimates arterial deformation by up to 143%, requiring approximately 6.5 mm of modeled supporting tissue to reduce error to below 10%.
Why the study?
Does the inclusion of surrounding supporting tissue affect the calculated radial deformation and compliance of healthy and diseased arteries in computational models?
Does the inclusion of surrounding supporting tissue affect the calculated radial deformation and compliance of healthy and diseased arteries in computational models?
Computational models of arterial compliance must include at least 6.5 mm of surrounding supporting tissue to avoid significant overestimation of arterial deformation.
Answers are grounded in this paper and cite their sources.
Accurate FSI modeling requires surrounding tissue to avoid overestimating compliance by up to 140%; leaves open clinical translation pending in vivo validation.
Hemodynamics and the interaction between the components of the cardiovascular system are complex and involve a structural/fluid flow interaction. During the cardiac cycle, changes to vascular pressure induce a compliant response in the vessels as they cyclically stretch and relax. The compliance influences the fluid flow throughout the system. The interaction is influenced by the disease state of the artery, and in particular, a plaque layer can reduce the compliance. In order to properly quantify the fluid-structural response, it is essential to consider whether the tissue surrounding the artery provides a support to the vessel wall. Here, a series of calculations are provided to determine what role the supporting tissue plays in the vessel wall and how much tissue must be included to properly carry out future fluid-structure calculations. Additionally, we calculate the sensitivity of the compliance to material properties such as the Young’s modulus or to the transmural pressure difference.
No takes yet. Share an insight, caveat, or question.
Sun et al. (2015) studied Arterial compliance and deformation. Supporting tissue sheath vs. No supporting tissue was evaluated on Radial deformation of the inner surface of the artery wall. Neglecting surrounding tissue in computational models overestimates arterial deformation by up to 143%, requiring approximately 6.5 mm of modeled supporting tissue to reduce error to below 10%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: