January 7, 2025Frontiers in Public Health10 citationsOpen Access

Higher triglyceride-glucose index and triglyceride glucose-body mass index protect against sarcopenia in Chinese middle-aged and older non-diabetic women: a cross-sectional study

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Sarcopenia (n=460). Intervention: Triglyceride glucose-body mass index (TyG-BMI) vs. Lower TyG-BMI index. Primary outcome: Sarcopenia (OR 0.948, 95% CI 0.934-0.962, p=<0.001).

MLMin Li YLYing Liu LGLei Gao

Key Result

Higher triglyceride glucose-body mass index (TyG-BMI) was significantly associated with a decreased risk of sarcopenia in non-diabetic postmenopausal women (OR 0.948).

Study Design

Type

Cross-Sectional (n=460)

Multicenter

Structured PICO

Are higher TyG index and TyG-BMI index associated with a lower risk of sarcopenia in non-diabetic middle-aged and older women?

Population

460 non-diabetic postmenopausal women aged 50 years and older were evaluated in a cross-sectional study to assess the association between TyG and TyG-BMI indices and sarcopenia.

Exposure

Higher triglyceride-glucose (TyG) index and TyG-body mass index (TyG-BMI)

Comparator

Lower TyG index and TyG-BMI index (evaluated by quartiles)

Outcome

Sarcopenia, defined by the Asian Working Group for Sarcopenia 2019 (AWGS 2019) criteria (low muscle mass plus low muscle strength and/or low physical performance)surrogate

The TyG-BMI index is a reliable and cost-efficient biomarker that is inversely associated with the risk of sarcopenia in non-diabetic middle-aged and older women.

Main Result

Odds Ratio: 0.948 (95% CI 0.934–0.962)

p-value: p=<0.001

Limitations

Cross-sectional design cannot establish a cause-and-effect relationship
Single-center study with a relatively small sample size
Unclear if findings are applicable to individuals of other ethnicities or in other countries
Potential covariates such as dietary intake and supplements were not examined

Abstract

Purpose: Sarcopenia, an age-related complication, constitutes a major public health problem given the aging of the population. However, it is frequently overlooked and undertreated in mainstream practice. The study aimed to investigate the correlations between triglyceride-glucose (TyG) index and TyG-body mass index (BMI) and sarcopenia in non-diabetic middle-aged and older women and whether they would be helpful indicators of sarcopenia. Patients and methods: This cross-sectional study was conducted in the Department of Endocrinology, Hebei Medical University Third Hospital. This study prospectively enrolled 460 non-diabetic postmenopausal women aged ≥50 years. Results: As TyG and TyG-BMI increased, the prevalence of sarcopenia decreased. In multivariate analysis, the TyG index and TyG-BMI index were inversely associated with sarcopenia (OR: 0.492; 95% CI: 0.256-0.944 and OR: 0.948; 95% CI: 0.934-0.962). Women in the fourth TyG-BMI quartiles showed decreased OR of 0.009 (95% CI: 0.001-0.072) for sarcopenia with respect to first quartiles after adjusting confounding factors. The area under the curve (AUC) for TyG index in the diagnosis of sarcopenia was 0.598 (95% CI: 0.529-0.666), while the AUC for TyG-BMI index was 0.858 (95% CI: 0.816-0.899). Conclusion: Higher TyG index and TyG-BMI index protected against sarcopenia in non-diabetic middle-aged and older females. Moreover, the TyG-BMI index was a reliable and cost-efficient biomarker to predict sarcopenia.

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Cite This Study

Li et al. (Tue,) conducted a cross-sectional in Sarcopenia (n=460). Triglyceride glucose-body mass index (TyG-BMI) vs. Lower TyG-BMI index was evaluated on Sarcopenia (OR 0.948, 95% CI 0.934-0.962, p=<0.001). Higher triglyceride glucose-body mass index (TyG-BMI) was significantly associated with a decreased risk of sarcopenia in non-diabetic postmenopausal women (OR 0.948).

synapsesocial.com/papers/6a6ccfe65d37378ac1db5b49 https://doi.org/https://doi.org/10.3389/fpubh.2024.1475330

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