Design
Review
Key result
Sustained activation of PDE5 by cGMP acts as a negative feedback mechanism in NO/cGMP signaling, allowing cells to adapt to available nitric oxide levels.
Authors
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New GC activators may enable isoform-specific targeting; leaves open cardiovascular therapeutic translation.
Key points are not available for this paper at this time.
M Pauler Florian (2005) reported a review. Sustained activation of PDE5 by cGMP acts as a negative feedback mechanism in NO/cGMP signaling, allowing cells to adapt to available nitric oxide levels.