March 14, 2000Proceedings of the National Academy of Sciences

Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses

View Full Paper

Ask AI

Bookmark

Population

Cerebellar cells and human platelets

Design

Preclinical

Authors

TBTomas C. BellamyUniversity of Nottingham JWJohn G. WoodUniversity of East Anglia DGDavid A. GoodwinSwansea University

Discussion

Member takes

Implication

May shape NO donor response timing; leaves open sGC desensitization as a cGMP regulatory target in vivo.

Structured PICO

Population

Cerebellar cells and human platelets

Intervention

Nitric oxide (from diethylamine NONOate)

Outcome

sGC activity and cGMP accumulation/degradation ratessurrogate

Soluble guanylyl cyclase undergoes rapid desensitization in intact cells, revealing a novel regulatory mechanism for shaping cellular cGMP responses to nitric oxide.

Cite This Study

Bellamy et al. (2000) studied this question.

synapsesocial.com/papers/6a843c2c002ab1506fb2a4d8 https://doi.org/10.1073/pnas.97.6.2928

View Full Paper

Ask AI

Bookmark

Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider