Key result
The SK channel inhibitor AP14145 successfully reverted vernakalant-resistant atrial fibrillation to sinus rhythm and prevented reinduction in 100% (8 of 8) of tested pigs.
Why the study?
Does the SK channel inhibitor AP14145 revert vernakalant-resistant atrial fibrillation in a porcine model?
Does the SK channel inhibitor AP14145 revert vernakalant-resistant atrial fibrillation in a porcine model?
Absolute Event Rate: 100% vs 0%
Pharmacological inhibition of SK channels with AP14145 effectively terminates vernakalant-resistant atrial fibrillation in a porcine model, highlighting SK channels as a promising antiarrhythmic target.
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SK channel inhibition terminates vernakalant-resistant AF in pigs; leaves open translation to human efficacy and safety.
Diness et al. (2017) studied Vernakalant-resistant atrial fibrillation (n=43). AP14145 vs. Vernakalant was evaluated on Reversion of vernakalant-resistant AF to sinus rhythm. The SK channel inhibitor AP14145 successfully reverted vernakalant-resistant atrial fibrillation to sinus rhythm and prevented reinduction in 100% (8 of 8) of tested pigs.
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