Key result
Each additional baseline cardiovascular risk factor was associated with an increased risk of death (HR 1.23; 95% CI 1.08-1.40; P=0.002) and cardiac events (HR 1.41; 95% CI 1.17-1.69; P<0.001).
Why the study?
Do baseline cardiovascular risk factors increase the risk of mortality and cardiac events in older patients with breast cancer?
Population
1,460 patients older than 66 years of age with breast cancer enrolled in five SWOG clinical trials, median…
Comparison
Presence of baseline cardiovascular disease risk… vs Fewer or no baseline cardiovascular disease risk…
Design
Cohort
Follow-up
median 6 years
Authors
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Each additional baseline CVD-RF was associated with higher cardiac events and mortality; supports risk-factor screening in survivors but leaves causal effects and practice change open.
Cohort (n=1,460)
Yes
Do baseline cardiovascular risk factors increase the risk of mortality and cardiac events in older patients with breast cancer?
Hazard Ratio: 1.23 (95% CI 1.08–1.4)
p-value: p=0.002
In older patients with breast cancer, a higher burden of baseline cardiovascular risk factors is significantly associated with increased risks of both cardiac events and overall mortality.
Hershman et al. (2018) conducted a cohort in Breast cancer (n=1,460). Cardiovascular disease risk factors (CVD-RFs) vs. Fewer or no cardiovascular disease risk factors was evaluated on Overall survival (HR 1.23, 95% CI 1.08-1.40, p=0.002). Each additional baseline cardiovascular risk factor was associated with an increased risk of death (HR 1.23; 95% CI 1.08-1.40; P=0.002) and cardiac events (HR 1.41; 95% CI 1.17-1.69; P<0.001).
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