Key result
Carvedilol at 1 μmol/l, but not propranolol, significantly blocked the 71% increase in oxidative stress induced by high pressure in cultured human coronary smooth muscle cells.
Why the study?
Does carvedilol reduce pressure-induced oxidative stress in cultured human coronary smooth muscle cells?
Population
Cultured human coronary smooth muscle cells (SMCs)
Comparison
Carvedilol added during 48 hours of increased… vs Propranolol or untreated control cells under the…
Design
Preclinical
Follow-up
48 hours
Authors
Loading...
In vitro pressure augments SMC oxidative stress; hypothesis-generating for hypertension-accelerated atherosclerosis and should not change practice.
Does carvedilol reduce pressure-induced oxidative stress in cultured human coronary smooth muscle cells?
p-value: p=<0.05
Carvedilol, unlike propranolol, directly inhibits pressure-induced increases in oxidative stress and migration in cultured human coronary smooth muscle cells, suggesting a potential mechanism for vascular protection in hypertension.
Yasunari et al. (2002) studied Cultured human coronary smooth muscle cells. Carvedilol vs. Propranolol or untreated control was evaluated on Intracellular oxidative stress measured by flow cytometry (p=<0.05). Carvedilol at 1 μmol/l, but not propranolol, significantly blocked the 71% increase in oxidative stress induced by high pressure in cultured human coronary smooth muscle cells.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: