Key result
High baseline serum ICAM-1 and VCAM-1 in initially healthy 58-year-old men were associated with increased risk of femoral artery plaque (OR 2.8, 95% CI 1.8-4.3 and OR 1.6, 95% CI 1.1-2.5).
Why the study?
Are baseline serum concentrations of ICAM-1 and VCAM-1 associated with future cardiovascular events and plaque occurrence in initially healthy middle-aged men?
Cohort
Are baseline serum concentrations of ICAM-1 and VCAM-1 associated with future cardiovascular events and plaque occurrence in initially healthy middle-aged men?
Odds Ratio: 2.8 (95% CI 1.8–4.3)
Baseline ICAM-1/VCAM-1 levels may predict events and plaques in men; leaves open clinical utility pending prospective validation.
The objective of the present study was to investigate if there was a difference in baseline serum concentrations of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) between groups with and without cardiovascular events during a mean follow-up of 6.6 years in a group of initially healthy 58-year-old men. A further aim was to examine if high serum concentrations of ICAM-1 and VCAM-1 were associated with carotid and femoral artery plaque occurrence, separately. Men with cardiovascular events during follow-up had higher median serum ICAM-I and VCAM-I than those without events (P < .05). The median of serum ICAM-I and VCAM-1 in the event group was used as the cutoff level, and in those with ICAM-1 and VCAM-1 above the cutoff value, there was an increased risk of having a plaque in the femoral artery (OR = 2.8, 95% CI = 1.8-4.3; and OR = 1.6, 95% CI = 1.1-2.5, respectively).
No takes yet. Share an insight, caveat, or question.
Schmidt et al. (2008) conducted a cohort in Initially healthy. High baseline serum ICAM-1 and VCAM-1 vs. Levels below the median cutoff was evaluated on Femoral artery plaque occurrence (OR 2.8, 95% CI 1.8-4.3). High baseline serum ICAM-1 and VCAM-1 in initially healthy 58-year-old men were associated with increased risk of femoral artery plaque (OR 2.8, 95% CI 1.8-4.3 and OR 1.6, 95% CI 1.1-2.5).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: