Key result
Total hydroxyproline content per mg dry weight of the left ventricle increased proportionally with heart weight (r = 0.48, p < 0.01).
Cross-Sectional (n=45)
No
Total hydroxyproline content (a marker of collagen) in the left ventricle increases proportionally with heart weight, suggesting that connective tissue participates in the hypertrophic process of human heart muscle.
Autopsy hydroxyproline data warrant caution in fibrosis assessment; leaves open collagen dynamics in living hearts.
Hydroxyproline content was chemically determined on 45 human hearts obtained at autopsy in order to study whether hydroxyproline contents vary in proportion to heart weight or not. There were no significant differences in the mean hydroxyproline content between the epicardium and the endocardium, between the left ventricle and the right ventricle, or among cardiovascular and renal disease group, malignant disease group and miscellaneous disease group. Total hydroxyproline content per mg dry weight of the left ventricle increased proportionally with heart weight. Hydroxyproline content in neutral salt soluble fraction increased more proportionally than that in acid soluble fraction. This tendency was more evident in the endocardium than in the epicardium of the left ventricle. These results seem to be well consistent with those of histometrical estimation of scar tissue in human heart muscle. Hydroxyproline content in acid soluble fraction of the right ventricle was increased proportionally with heart weight.
No takes yet. Share an insight, caveat, or question.
SASAKI et al. (1975) conducted a cross-sectional in Autopsy cases (various diseases) (n=45). Heart weight was evaluated on Correlation between total hydroxyproline content per mg dry weight of the left ventricle and heart weight (r = 0.48, p=<0.01). Total hydroxyproline content per mg dry weight of the left ventricle increased proportionally with heart weight (r = 0.48, p < 0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: