Ventricular hypertrophy was accompanied by an increase in the total mass of collagen regardless of cause, while collagen concentration was increased in patients with aortic stenosis.
Observational
Ventricular hypertrophy is accompanied by an increase in total collagen mass, but collagen concentration only increases if collagen mass outpaces muscle cell mass, as seen in aortic stenosis.
Estimates of the collagen concentration in human ventricles have been made from measurements of the hydroxyproline concentration. In the normal heart the concentration of collagen was higher in the right ventricle than in the left ventricle. Age had no effect on the ventricular concentration of collagen. Hypertrophy in the absence of a valvar lesion was not associated with an increased concentration of collagen but, owing to the increased size of the ventricle, there was an increase in the estimated total mass of ventricular collagen. The concentration of collagen in the left ventricle of patients with aortic stenosis was higher than normal. Ventricular hypertrophy seems to be accompanied by an increase in the total mass of collagen whatever the cause. Whether the concentration changes or not depends on the proportion in which the mass of collagen increases relative to the mass of muscle cells.
Caspari et al. (Tue,) conducted a observational in Ventricular hypertrophy. Ventricular hypertrophy vs. Normal ventricles was evaluated on Collagen concentration and total mass. Ventricular hypertrophy was accompanied by an increase in the total mass of collagen regardless of cause, while collagen concentration was increased in patients with aortic stenosis.