Key result
Aging in male Fischer 344 rats increased myocardial collagen from 5.5% to 12% in the left ventricle and from 7% to 19.5% in the right ventricle between 1 and 26 months of age.
Authors
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Highlights fibrosis as potential driver of age-related dysfunction; leaves open human translation and clinical relevance.
Eghbali et al. (1989) studied Myocardial collagen accumulation. Aging vs. 1 month old animals was evaluated on Total amount of myocardial collagen as a percentage of total protein. Aging in male Fischer 344 rats increased myocardial collagen from 5.5% to 12% in the left ventricle and from 7% to 19.5% in the right ventricle between 1 and 26 months of age.
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