Key result
Aging in a sheep model of heart failure resulted in divergent extracellular matrix remodeling, with collagen depletion in aged animals (P<0.05) versus accumulation in young animals (P<0.001).
Why the study?
Does aging exacerbate structural and functional remodeling of the myocardium in heart failure induced by right ventricular tachypacing in sheep?
Population
Young (~18 months) and aged (>8 years) sheep
Comparison
Heart failure induced by right ventricular… vs Non-paced animals (young and aged controls)
Design
Preclinical
Authors
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Hypothesis-generating for age-related HF remodeling in large animals; requires human validation before clinical consideration.
Does aging exacerbate structural and functional remodeling of the myocardium in heart failure induced by right ventricular tachypacing in sheep?
p-value: p=<0.05
In a sheep model of heart failure, aging leads to divergent extracellular matrix remodeling, with collagen accumulation in young animals but depletion in aged animals.
Horn et al. (2012) studied Heart failure. Aging vs. Young animals was evaluated on Cardiac extracellular matrix (ECM) remodeling (collagen content) (p=<0.05). Aging in a sheep model of heart failure resulted in divergent extracellular matrix remodeling, with collagen depletion in aged animals (P<0.05) versus accumulation in young animals (P<0.001).
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