Why the study?
The proteomic composition of the cardiac extracellular matrix and how it changes with age is not fully resolved.
This review summarizes the composition of the cardiac extracellular matrix and its remodeling and functional changes associated with aging.
ECM changes may elevate age-related arrhythmia risk; leaves open human proteomic studies to extend animal data.
The cardiac extracellular matrix (ECM) is involved in several pathological conditions, and age itself is also associated with certain changes in the heart: it gets larger and stiffer, and it develops an increased risk of abnormal intrinsic rhythm. This, therefore, makes conditions such as atrial arrythmia more common. Many of these changes are directly related to the ECM, yet the proteomic composition of the ECM and how it changes with age is not fully resolved. The limited research progress in this field is mainly due to the intrinsic challenges in unravelling tightly bound cardiac proteomic components and also the time-consuming and costly dependency on animal models. This review aims to give an overview of the composition of the cardiac ECM, how different components aid the function of the healthy heart, how the ECM is remodelled and how it is affected by ageing.
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Ringström et al. (2023) studied this question.
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