Why the study?
Does exercise training alter aging-induced changes in collagen characteristics of the left ventricle and papillary muscle in rats?
Population
Female Fischer 344 specific pathogen-free rats, young adult (5-month-old) and senescent (23-month-old)
Comparison
10 weeks of treadmill running (exercise training) vs Age-matched sedentary controls
Design
Preclinical
Follow-up
10 weeks
Authors
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Attenuates age-related ventricular collagen cross-linking in senescent rats; leaves open translation to human diastolic function.
Does exercise training alter aging-induced changes in collagen characteristics of the left ventricle and papillary muscle in rats?
Exercise training attenuates the age-related increase in left ventricular collagen cross-linking in senescent rats, which may favorably impact myocardial stiffness and contractile function.
Thomas et al. (1992) studied this question.
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