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January 1, 1993Japanese Circulation Journal-english Edition12 citationsOpen Access

Biochemical Remodeling of Collagen in the Heart of Spontaneously Hypertensive Rats. Prominent Increase in Type V Collagen.

Key result

In spontaneously hypertensive rats, cardiac hypertrophy development was associated with a prominent increase in the proportion of type V collagen compared to age-matched controls (p<0.01).

Authors

MHMasaaki HondaYGY GotoHKHiroshi Kuzuo

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Overview

PICO

P
Population
Spontaneously hypertensive and Wistar-Kyoto rats aged 10 to 40 weeks evaluated for cardiac collagen remodeling.
E
Exposure / Comparator
Spontaneous hypertension vs Wistar-Kyoto (WKY) rats
O
Primary Outcome
Collagen concentration and proportions of types I, III, and V collagen, p=<0.01

Main Result

p-value: p=<0.01

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Cite This Study

Honda et al. (1993) studied Cardiac hypertrophy. Spontaneous hypertension vs. Wistar-Kyoto (WKY) rats was evaluated on Collagen concentration and proportions of types I, III, and V collagen (p=<0.01). In spontaneously hypertensive rats, cardiac hypertrophy development was associated with a prominent increase in the proportion of type V collagen compared to age-matched controls (p<0.01).

synapsesocial.com/papers/6a97332f155d38739b89d41ehttps://doi.org/10.1253/jcj.57.434
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