Key result
Spontaneously hypertensive rats exhibited a marked increase in MMP-1 mRNA levels with age (+187% at 30 weeks, p<0.01) and reduced TIMP-1 compared to Wistar-Kyoto rats.
Authors
Loading...
Animal data on MMP-1/TIMP-1 imbalance should not change practice; hypothesis-generating for remodeling mechanisms in human hypertension.
Teresa Maria Seccia (1999) studied Left ventricular hypertrophy and hypertension. Spontaneously hypertensive rats (SHR) vs. Wistar-Kyoto (WKY) rats was evaluated on Extracellular matrix gene expression (MMP-1, TIMP-1, procollagen alpha1(I) and alpha1(III), fibronectin). Spontaneously hypertensive rats exhibited a marked increase in MMP-1 mRNA levels with age (+187% at 30 weeks, p<0.01) and reduced TIMP-1 compared to Wistar-Kyoto rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: