Key result
Failing hearts from spontaneously hypertensive rats demonstrated increased perivascular and interstitial collagen alpha1(I) gene expression and focal mRNA accumulation compared to controls.
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Extends molecular evidence of fibrosis in hypertensive HF models; leaves open human relevance and therapeutic targeting.
Bing et al. (1997) studied Heart failure and myocardial hypertrophy. Spontaneous hypertension and heart failure vs. Non-hypertensive Wistar Kyoto rats (WKY) and non-failing SHR was evaluated on alpha1(I) collagen mRNA expression and localization. Failing hearts from spontaneously hypertensive rats demonstrated increased perivascular and interstitial collagen alpha1(I) gene expression and focal mRNA accumulation compared to controls.
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