What is the clinical evidence from this study?

Study design: Other. Population: Compensatory hypertrophy and decompensatory heart failure. Intervention: Decompensatory hypertrophy with heart failure vs. Compensatory hypertrophy and normotensive controls. Primary outcome: Elastin:collagen ratio (p=<0.001).

What question did this study set out to answer?

This research aims to understand how extracellular matrix components, specifically collagen and elastin, change during the transition from hypertrophy to heart failure.

February 1, 1999Journal of Hypertension

Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure

Q: What are the key findings of this study?

The transition to decompensatory heart failure in spontaneously hypertensive rats is associated with a marked decrease in the elastin:collagen ratio (0.012 vs 0.242 in controls) and increased MMP-2 activity (P<0.001).

Q: What question did this study set out to answer?

This research aims to understand how extracellular matrix components, specifically collagen and elastin, change during the transition from hypertrophy to heart failure.

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Key result

The transition to decompensatory heart failure in spontaneously hypertensive rats is associated with a marked decrease in the elastin:collagen ratio (0.012 vs 0.242 in controls) and increased MMP-2 activity (P<0.001).

Authors

VMVibhas S. MujumdarState Street (United States)STSuresh C. TyagiUniversity of Louisville

Discussion

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Implication

ECM remodeling may drive decompensation in hypertensive HF; hypothesis-generating for MMP-2 targeting in patients.

Key Points

This research aims to understand how extracellular matrix components, specifically collagen and elastin, change during the transition from hypertrophy to heart failure.
Prepared left ventricular tissue from spontaneously hypertensive rats (SHR) aged 30-36 weeks and 70-92 weeks; used Wistar-Kyoto rats as controls.
Measured collagen levels using immuno-blot analysis and quantified elastin and collagen via spectrophotometry.
Performed gelatin and elastin zymography to assess matrix metalloproteinase activity.
The elastin:collagen ratio significantly decreased in SHR with heart failure (0.012 +/- 0.005) compared to controls (0.242 +/- 0.008).
Increased activity of matrix metalloproteinase-2 was found in SHR with heart failure (P < 0.001).
Decorin levels were markedly reduced in decompensatory heart failure compared to control hearts.

PICO

Population

Compensatory hypertrophy and decompensatory heart failure

Intervention / Comparator

Decompensatory hypertrophy with heart failure vs Compensatory hypertrophy and normotensive controls

Primary Outcome

Elastin:collagen ratio, p=<0.001

Main Result

Absolute Event Rate: 0.012% vs 0.242%

p-value: p=<0.001

Cite This Study

Mujumdar et al. (1999) studied Compensatory hypertrophy and decompensatory heart failure. Decompensatory hypertrophy with heart failure vs. Compensatory hypertrophy and normotensive controls was evaluated on Elastin:collagen ratio (p=<0.001). The transition to decompensatory heart failure in spontaneously hypertensive rats is associated with a marked decrease in the elastin:collagen ratio (0.012 vs 0.242 in controls) and increased MMP-2 activity (P<0.001).

synapsesocial.com/papers/6a08685ead370a6b44de140f https://doi.org/10.1097/00004872-199917020-00011

Topics

Heart failure HFrEF treatment

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Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure

Discussion

Member takes

Implication

Key Points

PICO

Main Result

Cite This Study

Topics

Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure

Discussion

Member takes

Implication

Key Points

PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider