Why the study?
Do ACE inhibitors (captopril and lisinopril) alter collagen phenotypes during regression of cardiac hypertrophy in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats (SHR) and age- and sex-matched Wistar Kyoto (WKY) rats
Comparison
Antihypertensive therapy with ACE inhibitors vs Untreated SHR and WKY rats
Design
Preclinical
Follow-up
Up to 65 weeks of age
Authors
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Different ACE inhibitors may have distinct, blood pressure-independent effects on cardiac collagen phenotypes during hypertrophy regression.
Do ACE inhibitors (captopril and lisinopril) alter collagen phenotypes during regression of cardiac hypertrophy in spontaneously hypertensive rats?
Different ACE inhibitors may have distinct, blood pressure-independent effects on cardiac collagen phenotypes during hypertrophy regression.
Yang et al. (1997) studied this question.