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April 1, 1993Clinical and Experimental Pharmacology and Physiology

Angiotensin Converting Enzyme Inhibitor, Captopril, Inhibits Cardiac Hypertrophy Without Changing Collagen Types and Concentration in Spontaneously Hypertensive Rats

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Why the study?

Does captopril reduce cardiac hypertrophy and alter collagen metabolism in spontaneously hypertensive rats?

Population

20-week-old male spontaneously hypertensive rats (SHR) with cardiac hypertrophy

Comparison

Captopril 100 mg/kg per day administered in… vs Non-treated age and sex matched spontaneously…

Design

Preclinical

Follow-up

12 weeks

Authors

HKHiroshi KuzuoMHMasaaki HondaYIYuji Ishinaga

Discussion

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Overview

In spontaneously hypertensive rats, captopril reduces blood pressure and cardiac hypertrophy, lowering total collagen content without altering collagen concentration or type proportions.

Structured PICO

Does captopril reduce cardiac hypertrophy and alter collagen metabolism in spontaneously hypertensive rats?

P
Population
20-week-old male spontaneously hypertensive rats (SHR) with cardiac hypertrophy
I
Intervention
Captopril 100 mg/kg per day administered in drinking water for 12 weeks
C
Comparator
Non-treated age and sex matched spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
O
Outcome
Collagen concentration and relative proportions of types I, III and V collagensurrogate

In spontaneously hypertensive rats, captopril reduces blood pressure and cardiac hypertrophy, lowering total collagen content without altering collagen concentration or type proportions.

Cite This Study

Kuzuo et al. (1993) studied this question.

synapsesocial.com/papers/6a7683153a7d5cabaf295c0bhttps://doi.org/10.1111/j.1440-1681.1993.tb01678.x
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