Why the study?
Does MMPi or ACEi improve collagen, MMP, and TIMP expression and cardiac remodeling in spontaneously hypertensive heart failure rats?
Population
Spontaneously hypertensive heart failure rats and normotensive Wistar-Furth rats
Comparison
MMPi or ACEi orally administered for 4 months vs Untreated SHHFs and normotensive WF rats
Design
Preclinical
Follow-up
4 months
Authors
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Should not change clinical remodeling therapy; extends evidence of divergent MMP- versus ACE-inhibitor effects in hypertensive HF models.
Does MMPi or ACEi improve collagen, MMP, and TIMP expression and cardiac remodeling in spontaneously hypertensive heart failure rats?
MMP inhibition and ACE inhibition both attenuate cardiac remodeling in SHHF rats, but through divergent pathways as only ACE inhibition reduced collagen mRNA levels and hypertrophy.
H Li (2000) studied this question.
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